Full - Drug report, Montelukast, Asthma Treatment. structure function, metabolism, excretion.

Introduction Asthma is a common upset(a) associated with the respiratory system; it affects one and only(prenominal) in four prime school children, one in seven teenagers, and one in ten adults in Australia (Bryant et al, 2002). in that respect argon many mediators heterogeneous in the pathogenesis of an bronchial asthma advance attack attack, and the tartness of the symptoms depose vary between individuals. in that respect ar several(prenominal) drugs that have been demonstrable to treat the dis arrange, with differing mechanisms of action such(prenominal)(prenominal) as sympathomimetics, corticosteroids, leukotriene receptor antagonists and mast-cell stabilizers. This flake deals with the leukotriene receptor antagonist montelukast. Montelukast has been shown to be peculiarly effective in treating children with both mild recollective asthma and frequent casual asthma (Knorr et al, 2001; Nat. Asthma Council, 2002), and individuals with aspirin-sensitive asthma (Seale, 1999). It is prone orally as the sodium salt of this compound (Singulair w atomic number 18 Information, 2003), the structural formulation is shown below Pathophysiology of Asthma As already stated, asthma is a disorder of the respiratory system, it occurs when the musical passage in and out becomes forbid repayable to reversible bronchoconstricition, continuing inflammation of the epithelium of the airways, and increase mucose secretion (Bryant et al, 2002). in that location ar many factors tortuous in the pathogenesis of asthma; such as leukotrienes, histamine, prostaglandins and other cytokines.

thither are two chief(prenominal) types of asthma; extrinsic (atopic, allergic) and intrinsic. adventitious asthma is triggered by substances that are not normally put in in the body such as allergens like pollen, scatter mites and living creature fur. congenital is Mechanism of Action of Montelukast Put simply, montelukast is a reversible, warring antagonist of leukotrienes selective for the CysLT1 receptor. The leukotrienes are products of arachidonic acid metabolism by 5-lipoxygenase (Borgeat et al, 1976), as shown in externalize 1; there are 5 leukotrienes: LTA4, LTB4, LTC4, LTD4 and LTE4, of which the... If you requirement to suck a full essay, order it on our website: Ordercustompaper.com

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